This Harvard study explored the biological changes that occur in the muscles during Post-exertional Malaise (PEM). The Computation Center is now seeking to identify drug targets to prevent PEM.
Powerful genomic research tools used to understand cancer and heart disease might also help us understand why people with ME/CFS develop post-exertional malaise (PEM). The way that genes in ME/CFS patients behave differently from those in healthy comparable subjects might give tremendous insight for a biomarker or drug targets to combat PEM and fatigue.
The hypothesis is that the inflammation-related recovery mechanisms become dysfunctional in the ME/CFS disease, and this dysregulation causes delayed muscle recovery after exertional stress.
This hypothesis will be tested by analysing nearly 100 muscle biopsy samples from healthy subjects whose ages, sex, and lifestyles match those of ME/CFS patients as closely as possible. Careful comparison to these samples will be critical to detect subtle differences in the genes responsible for a healthy recovery from muscular exercise.
Donate your appreciated stock directly to OMFCA and you can receive an immediate income-tax deduction for the fair market value of the securities on the date of transfer (even if you originally paid much less for them).
OMFCA sells your securities and uses the proceeds to support our mission. You also do not pay capital gains tax on the transfer when the stock is sold. Giving appreciated stock can be more beneficial than giving cash. The “cost” of your gift is often less than the deduction you gain by making it. In advance, thank you for making this generous gift.
Gifting of Stock Instructions
Brokerage/Investment Firm: TD Waterhouse
Name on the Account: Open Medicine Foundation Canada
Account Number: 20LRHLA
OMFCA Canadian Revenue Agency (CRA) charity registration #: 74926 5518 RR0001
OMF Canada Registered Address:
Open Medicine Foundation Canada
2987 Baynes Road, Victoria, BC V8N-1Y4
Phone Number: 416-848-0055
Please speak to your personal tax advisor and then call OMFCA at 650-242-8669 to notify us of your donation or with any questions.