STUDY HYPOTHESIS AND DESCRIPTION
Previously, autoantibodies have been observed to have increased binding to adrenergic and muscarinic receptors in Myalgic Encephalomyelitis/ Chronic fatigue syndrome (ME / CFS) patients. It is hypothesized that these autoantibodies may be part of the pathogenesis of ME / CFS and patient symptom.
STUDY DESIGN
Plasma, CSF and health-related questionnaires were collected from two Swedish ME / CFS cohorts, plasma and CSF from one of the cohorts (n=24), only plasma from the second cohort (n=24) together with plasma samples (n=24) and CSF (n=6) from healthy controls.
All samples were analyzed for IgG autoantibodies directed against adrenergic and muscarinic receptors ELISA technique. The questionnaires were used as measures of disease severity.
This study has been published in Brain, Behavior and Immunity – Health