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Category: News

An Update from Dr. Chris Armstrong: The Science Behind Hope

Today, we’re sharing an update on important developments in ME/CFS research — work that is steadily improving our understanding of the biology behind this complex and often life-altering condition. Whether a person’s ME/CFS began decades ago or more recently, the challenges are real and often devastating. Our research is focused on uncovering the underlying mechanisms […]

Update: MRI and PET Imaging of ME/CFS, POTS, and Long COVID

From the Desk of Dr. Danielle Meadows, Vice President of Research Programs & Operations In the fall of 2024, I introduced to you all an overview of the research process, where studies typically move through four main stages: Study Design, IRB/Ethics Review; Recruitment, Data Collection; Data Analysis; and Publication.  Given that context, I then shared […]

OMF CRCs Directors Meet in Person to Advance Research

In May, I had the privilege of attending the 2025 Invest in ME Research International Conference in Cambridge, UK, along with OMF’s research Directors. This annual event brings together scientists, clinicians, and advocates committed to advancing ME/CFS and Long COVID research worldwide. Following the conference, OMF’s CRC Directors gathered for an additional two-day, in-person meeting. […]

🧬Science Wednesdays: Statistics 101

This image is a conceptual representation of statistics and data analysis. It features a group of professionals collaborating at a desk with a city skyline illuminated at night. Overlaid on the image are various graphical elements associated with data, such as bar charts, radar charts, pie charts, and data points.

Statistics 101 From the Desk of Dr. Danielle Meadows Vice President of Research Programs & Operations A few months ago, I started talking about evaluating research studies by going through what it means to be a well-powered study. As part of that discussion (you can read it here if you missed it), I mentioned statistical […]

New Publication from the OMF’s Collaborative Center at Uppsala

We’re pleased to share a new publication by Jonas Bergquist, MD, PhD, and colleagues: “Comprehensive transcriptome assessment in PBMC of post-COVID patients at two years after a mild COVID infection reveals upregulation of JAK/STAT signaling and chronic inflammation.” The Heart of the Matter The Director of OMF’s Collaborative Center at Uppsala, Dr. Jonas Bergquist, recently published […]

Myalgic Encephalomyelitis Adaptive Therapeutic Solution Platform (MEDUSA)

From the Desk of Dr. Danielle MeadowsVice President of Research Programs & Operations The four major stages of the research process that I’ve laid out in previous messages are generally applicable to any given clinical research study. But sometimes, this process can be almost cyclical rather than standalone, which is the case for the new […]

Research Update: Refining a Diagnostic Model and Designing a New PEM Project

May Momentum logo- You are the motivation behind our momentum

As part of our May Momentum campaign, we are excited to share an interview with Chris Armstrong, PhD, and post-doctoral researcher, Kathy Huang, PhD, about their ongoing ME/CFS research. Please consider making a donation today to support our ongoing research efforts and bring us closer to finding effective diagnostics and treatments for millions worldwide. Every contribution, […]

Honoring ME/CFS Awareness Day

Today, on International ME/CFS Awareness Day (May 12), we stand together to honor every person living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—a disabling, life-altering disease that still lacks a diagnostic test, effective treatments, and a cure. This day is a reminder of the strength and resilience within our community—and of the urgent need for answers. […]

Bridie’s Story: The Hidden Struggle of Living with ME/CFS

As we approach ME/CFS Awareness Day on May 12, we reflect on the life-altering impact of this debilitating disease.  Characterized by profound fatigue, cognitive impairment, pain, and a range of other disabling symptoms, ME/CFS often leaves people housebound or bedbound—unable to take part in activities that others often take for granted. Despite affecting millions worldwide, […]

OMF Australia Marks 4th Anniversary: Progress, Hope, and Our Path Forward

As Open Medicine Foundation (OMF) begins its thirteenth year, we recently marked a significant milestone – the fourth anniversary of Open Medicine Foundation (OMF) Australia – with a special gathering in Melbourne. Hosted at the historic Cranlana House, the event brought together researchers, board members, and key partners. It was a particularly meaningful occasion as […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.