The Harvard ME/CFS Collaboration

at the Harvard Affiliated Hospitals

Clinical and scientific studies to understand ME/CFS and discover new treatments

Core Aims

What we hope to achieve

Philosophy

Our fundamental philosophy

Science Team

List of scientific collaborators

Research

Current research projects

About the research centre

Established in 2018, this research initiative is based at Harvard affiliated hospitals, including Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and Beth Israel Deaconess Medical Center (BIDMC). 

Including the faculty of the Harvard affiliated hospitals, critical collaborations are represented from Stanford University, Cornell University, University of Birmingham, University of Nottingham, Uppsala University and Pacific Northwest National Laboratory. 

This collaborative research centre is co-led by Ronald G. Tompkins, MD, ScD and Wenzhong Xiao, PhD. This research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of ME/CFS patients. 

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Ronald G. Tompkins, MD, ScD
Wenzhong Xiao, PhD

Core Aims

Fundamental Philosophy

  • Work collaboratively with other groups
  • Use the most advanced technology available to perform the research
  • Explore the research community to find experts in the areas to study
  • Take direct measures from ME/CFS patients to avoid artificial observations
  • Research multiple tissues of the body and consider stark differences of different cell types

The Research

Co-led by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD., this research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of ME/CFS patients. 

Current Studies

Multi-omics of iCPET Plasma Samples

Multi-omics of iCPET Plasma Samples STUDY AIM This project aims to understand the origin of postural orthostatic tachycardia syndrome (POTS). LEAD INVESTIGATORS Ronald Tompkins, MD …

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Skeletal Muscle Dysfunction Research

Skeletal Muscle Dysfunction Research STUDY AIM This project aims to explore the biological changes that occur in the muscles during Post-exertional Malaise (PEM). LEAD INVESTIGATORS …

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Heart Preload Failure

Heart Preload Failure STUDY AIM This study aims to evaluate these different explanations of PLF in ME/CFS patients to determine which is active in many, …

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Brain Nuclear Inflammation

Brain Nuclear Inflammation STUDY AIM This project aims to better understand the role of neuroinflammation in ME/CFS. LEAD INVESTIGATORS Ronald Tompkins, MD, ScD Wenzhong Xiao, …

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Computerized Adaptive Testing

Computerized Adaptive Testing TECHNOLOGY AIM Given meager research funding and the absence of a consensus on disease mechanism, there has been no definition or single …

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Scientific Team

To carry out these ambitious collaborations, Drs. Tompkins and Xiao together with the many Harvard Medical School faculty are establishing networks and collaborations extending to the UK and other US-based institutions. They have assembled a team of superb clinicians and scientists with expertise in a wide variety of areas directly relevant to ME/CFS research. 

Massachusetts General Hospital

Ronald Tompkins, MD, ScD

Wenzhong Xiao, PhD

Donna Felsenstein, MD

Jonathan Friedstat, MD

Daniel Irimia, MD, PhD

Amel Karaa, MD

Michael VanElzakker, PhD

H. Shaw Warren, MD

Yongming Yu, MD, PhD

Andrew Alexander, MBA

Brigham & Womens Hospital

David Systrom, MD

Anthony Komaroff, MD

 

BI Deaconess Medical Center

Janet Mullington, PhD

 

Pacific Northwest National Laboratory

Richard Smith, PhD

John Jacob, PhD

Wei-Jun Qian, PhD

University of Nottingham, UK

Philip Atherton, PhD

Paul Greenhaff, PhD

 

University of Birmingham, UK

Janet Lord, PhD

 

Cornell University

Maureen Hanson, PhD

Open Medicine Foundation

Linda Tannenbaum

Chris Armstrong, PhD

 

Stanford University

Ronald Davis, PhD

 

Uppsala University, Sweden

Jonas Bergquist, MD, PhD