The Life Improvement Trial (LIFT)
The Life Improvement Trial (LIFT) aims to investigate two drugs, separately and in combination, Pyridostigmine (commonly known as Mestinon) and Low-Dose Naltrexone (LDN), for efficacy and to research the difference between responders and non-responders.
Temporally Resolved Omics Tracking of ME/CFS
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
Network Medicine for Disease Mechanisms and Treatment
The goal of this project is to use data integration and network analyses to discover disease mechanisms and potential treatments.
iCPET Omics Studies of ME/CFS
This Harvard study evaluates the different explanations of heart preload failure in ME/CFS patients to determine which is active in many, if not all, ME/CFS patients. The Computation Center is now seeking to better understand the causes of ME/CFS (PLF, the high flow type) as well as to identify potential drug targets for future therapies.
OMF Data Center
The purpose of the OMF Data Center is to house raw data and processed results, which is shared with our research network through the web-based data portal.
Skeletal Muscle Dysfunction
This project aims to explore the biological changes that occur in the muscles during Post-exertional Malaise (PEM).
Red Blood Cell Deformability in ME/CFS (RBC Biomechanics)
The goal of the project is to develop, characterize, and validate a microfluidic chip for the estimation of biomechanical properties of red blood cells (RBCs) isolated from ME/CFS patients vis-à-vis healthy controls.
Genetic and Metabolic Markers of BH4 Deficiency in Long COVID
This project aims to test whether
genetic markers and other indicators of BH4 deficiency are also present in subjects with Long COVID.
COVID to Long COVID to ME/CFS
OMF secured a $1 million grant to launch the first year of an international, multi-year study across the six OMF supported Collaborative Research Centers (CRC). The aim of this study is to examine Long COVID transitioning to ME/CFS.
Single Day Longitudinal Study
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).